2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-G0010
    Netupitant metabolite N-desmethyl Netupitant
    N-desmethyl Netupitant is a metabolite of Netupitant, which is an antiemitic drug.
    Netupitant metabolite N-desmethyl Netupitant
  • HY-168354
    Desmethylflutiazepam
    Desmethylflutiazepam (N-Desmethylfludiazepam) is a metabolite of various benzodiazepine compounds.
    Desmethylflutiazepam
  • HY-119223
    Desmethylmirtazapine
    Desmethylmirtazapine is an active metabolite of Mirtazapine that has antidepressant effects.
    Desmethylmirtazapine
  • HY-163038
    Sulfamethoxazole-NO hydrate
    Sulfamethoxazole-NO (SMX-NO) hydrate is the reactive metabolite of SMX (HY-B0322). Sulfamethoxazole-NO (SMX-NO) hydrate actis as a typical hapten and is capable of covalently modifying the MHC-peptide complex, can stimulate hapten-reactive T cells.
    Sulfamethoxazole-NO hydrate
  • HY-N8341
    Alphitonin
    		Control
    Alphitonin is a flavonoid and is also a metabolic intermediate that is formed during the catabolism of Quercetin (HY-18085) by the human gut bacteria E. ramulus.
    Alphitonin
  • HY-169330
    3β,5α,6β-Trihydroxycholanic acid
    3β,5α,6β-Trihydroxycholanic acid is a metabolite of 3β,5α,6β-Trihydroxycholestane (HY-W010934). 3β,5α,6β-Trihydroxycholanic acid can be used in research related to neurodegenerative diseases associated with lysosomal dysfunction.
    3β,5α,6β-Trihydroxycholanic acid
  • HY-W017431
    2,5-Dimethylbenzoic acid
    2,5-Dimethylbenzoic acid is one of the main urinary metabolites of Pseudocumene (1,2,4-trimethylbenzene) in rats. 2,5-Dimethylbenzoic acid can be used to quantitatively determine the inhalation exposure level of Pseudocumene.
    2,5-Dimethylbenzoic acid
  • HY-138166S
    Rosuvastatin lactone-d6
    Rosuvastatin lactone-d6 is the deuterium labeled Rosuvastatin lactone. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect.
    Rosuvastatin lactone-d<sub>6</sub>
  • HY-W587458
    Deoxycholic acid 3-sulfate disodium
    Deoxycholic acid 3-sulfate disodium is a steroid bile salt, a sulfate derivative of the bile acid (BA) deoxycholic acid.
    Deoxycholic acid 3-sulfate disodium
  • HY-Z4707
    Etoricoxib N1'-oxide
    		99.97%
    Etoricoxib N1'-oxide is an Etoricoxib (HY-15321) metabolite. Etoricoxib N1'-oxide does not inhibit COX-1, nor does it significantly inhibit COX-2.
    Etoricoxib N1'-oxide
  • HY-135194
    Risperidone E-oxime
    		98.97%
    Risperidone E-oxime is an impurity of Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively .
    Risperidone E-oxime
  • HY-126857R
    5-Hydroxyomeprazole (Standard)
    5-Hydroxyomeprazole (Standard) is the analytical standard of 5-Hydroxyomeprazole. This product is intended for research and analytical applications. 5-Hydroxyomeprazole is the major metabolite of Omeprazole (HY-B0113).
    5-Hydroxyomeprazole (Standard)
  • HY-G0002
    Lurasidone metabolite 14326
    Lurasidone metabolite 14326 is a minor active metabolite of Lurasidone (HY-B0032A) generated via metabolism by CYP3A4. Lurasidone metabolite 14326 shares similar receptor-binding properties with Lurasidone, acting as an antagonist of the dopamine D2 receptor (dopamine D2 receptor), an antagonist of the serotonin 5-HT2A and 5-HT7 receptors (5-HT2A and 5-HT7 receptor), and a partial agonist of the serotonin 5-HT1A receptor. Lurasidone metabolite 14326 can be used in the research of schizophrenia and bipolar depression.
    Lurasidone metabolite 14326
  • HY-176033
    ADB-FUBIATA BA
    ADB-FUBIATA BA (ADB-FUBIATA 3,3-dimethylbutanoic acid metabolite) is a metabolite of ADB-FUBIATA that is structurally similar to known synthetic cannabinoids.
    ADB-FUBIATA BA
  • HY-W015338
    1-(4-Methoxyphenyl)-1-propanol
    1-(4-Methoxyphenyl)-1-propanol (Compound 2) is an orally active derivative of anethole. 1-(4-Methoxyphenyl)-1-propanol exhibits significant antioxidant activity. 1-(4-Methoxyphenyl)-1-propanol has anti-inflammatory activity and moderate gastric protective activity in mice. 1-(4-Methoxyphenyl)-1-propanol can be used for the study of gastric ulcers.
    1-(4-Methoxyphenyl)-1-propanol
  • HY-Y0801R
    2,6-Dihydroxybenzoic acid (Standard)
    2,6-Dihydroxybenzoic acid (Standard) is the analytical standard of 2,6-Dihydroxybenzoic acid (HY-Y0801). This product is used for research and analytical applications. 2,6-Dihydroxybenzoic acid is an aromatic compound containing phenolic hydroxyl groups and carboxyl groups, and it is a secondary metabolite of Salicylic acid (HY-B0167). 2,6-Dihydroxybenzoic acid is also present in olive oil wastewater.
    2,6-Dihydroxybenzoic acid (Standard)
  • HY-116029
    Tolmetin β-D-Glucuronide
    Tolmetin β-D-Glucuronide (Tolmetin glucuronide) is the major phase II metabolite of Tolmetin (HY-B1799).
    Tolmetin β-D-Glucuronide
  • HY-148083
    TBBPA-sulfate
    TBBPA-sulfate is metabolite of TBBPA. TBBPA has been reported to enhance adipogenesis by binding with the peroxisome proliferator-activated receptor gamma (PPARγ).
    TBBPA-sulfate
  • HY-23331
    Propylene thiourea
    Propylene thiourea (4-Methylimidazolidine-2-thione) is one of the main degradation products of Propineb (HY-119630) in animals, plants and during processing.
    Propylene thiourea
  • HY-138128
    Acetaminophen mercapturate
    Acetaminophen mercapturate is a metabolite of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor.
    Acetaminophen mercapturate
Cat. No. Product Name / Synonyms Application Reactivity